Immunogenic lipid oxidation by oxidative stress in young people and the risk of early atherogenic endotelial dysfunction

Abstract Introduction The high presence of oxygen free radicals and low antioxidant enzymes values, trigger oxidative stress imbalance lipid oxidation, with immunogenic potential, thus the occurrence autoantibodies, endothelial lesional effect, accelerating onset early atherogenesis. A level in young people may also be involved development non-lesional cardiac arrhythmias. Purpose Assessment atherogenic risk arrhythmias, without dyslipidemia, by determining profile, through specific biomarkers (superoxide dismutase – SOD, glutathione peroxidase GPx, total status TAS), relation to oxidation (oxidized density lipoprotein oxLDL) autoantibodies anti-oxidized anti-oxLDL), a role dysfunction. Patients methods research was conducted on 120 subjects, 18–45 years old, divided into three equal groups: two groups (I, II) subjects who presented arrhythmic manifestations, 40 them dyslipidemia control group. TAS, as well oxLDL anti-oxLDL antibodies were determined, serum. Electrocardiogram investigations performed, order exclude pre-existing cardiovascular pathology or conditions that alter profile. Results decrease SOD TAS found, patients dyslipidemia. It associated an increased level, autoantibodies. Compared controls, both mean values reduced at 62–64% activity, 68–74% GPx 52–54% for up 206% those 161% without. OxLDL increased, 176% 140%. Highly statistical correlations (p<0.001) found between decreased anti-oxLDLox correlated Conclusions 1. Decreased is accelerated 2. Increased promote lesions, triggering subclinical atherosclerosis. 3. associates arrrhythmias people, autoimmunity antibodies. 4. Oxidized LDL dyslipidemic non-dyslipidemic patients, highly risk. Funding Acknowledgement Type funding sources: None.